赵兴洪 更新日期:2024-07-09
赵兴洪 ,男,1990年出生,学硕导师
工作单位 动物医学院
单位电话 028-86291162
电子邮箱 xinghong.zhao@sicau.edu.cn
招生专业 学硕:0906Z1动物药学,专硕:095200兽医
◆个人简历
赵兴洪,四川省特聘专家,四川农业大学动物医学院副教授,硕士生导师,入选四川省“天府峨眉计划”青年科技人才(原省千人计划),四川农业大学海外高层次引进人才。
博士毕业于荷兰格罗宁根大学(软科世界大学排名66)微生物与生化药学专业,师从荷兰皇家科学院院士,欧洲微生物科学院常务院士 Oscar Paul Kuipers教授。博士毕业后继续在Oscar教授实验室从事了博士后研究工作,随后入职四川农业大学。自攻读博士学位至今一直从事着新型抗生素的设计合成、作用机制及其精准高效递送策略的研究工作。经过十余年研究已开发出多种对大肠杆菌、肺炎克雷伯菌、绿脓杆菌、魏氏梭菌、艰难梭菌、金黄色葡萄球菌、粪肠球菌等病原菌具有良好抗菌活性的新型生物合成肽类抗菌剂,同时开发出了多种抗菌药物精准递送体系。
现已发表SCI收录论文30余篇,累计被引1200余次。现已发表SCI收录论文30余篇,累计被引1200余次,H指数20。研究成果发表在包括Nature Communications、Cell Chemical biology、Advanced Materials、Journal of Controlled Release、Advanced Healthcare Materials、International Journal of Biological Macromolecules和Antimicrobialagents and chemotherapy等权威期刊。聚焦畜禽细菌性腹泻病和母畜传染性乳房炎的新型防控策略研究。
◆工作经历
2023/03至今四川农业大学副教授
2021/08-2023/02 四川农业大学特聘副教授
2020/06–2021/08荷兰格罗宁根大学微生物与生化药学博士后
◆教育经历
2020/06–2021/08荷兰格罗宁根大学微生物与生化药学博士后
2017/08–2020/06荷兰格罗宁根大学微生物与生化药学博士
◆获奖荣誉
四川省特聘专家,入选四川省“天府峨眉计划”青年科技人才(原省千人计划),四川农业大学海外高层次引进人才。
◆社会、学会及学术兼职
荷兰皇家微生物学学会会员、美国微生物学会会员、Frontiers in Microbiology(IF=6.604, Top)客座编辑(Guest Editor)。
◆研究领域
新型肽类抗菌剂(基因组发掘与生物合成)、仿生纳米载药系统、细菌耐药性防控
◆科研项目
1、天府英才工程专项,2023.04-2026.03,在研,主持
2、四川省国际科技创新合作项目,202201-202312,结题,主持
3、四川农业大学引进人才科研启动项目,202108-202607,在研,主持
4、四川省博士后科研项目特别资助,202307-202507,在研,主持
◆发表论文
现已发表SCI收录论文30余篇,累计被引1200余次,H指数20。研究成果发表在包括NatureCommunications、Cell Chemical biology、Advanced Materials、Journal of Controlled Release、Advanced Healthcare Materials、International Journal of Biological Macromolecules和Antimicrobialagents and chemotherapy等权威期刊。
[1]Xinghong Zhao#,*, Xinyi Zhong#, Shinong Yang#, Jiarong Deng, Kai Deng, Zhengqun Huang, Yuanfeng Li, Zhongqiong Yin*, Yong Liu*, Jakob H. Viel, and Hongping Wan*. "Guiding antibiotics towards their target using bacteriophage proteins."NatureCommunications,2024, 15: 5287.(IF = 16.6,物理第一作者兼共同通讯作者)
[2]Xinghong Zhao, Zhibo Li, and Oscar P. Kuipers*. "Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification."Cell Chemical Biology,2020, 27(10): 1262-1271.(IF = 9.039,第一作者)
[3] Kai Deng#, Zhengqun Huang#, Bo Jing, Lin Zhu, Yumei Feng, Qin Jiang, Zhiwen Xu, Hongping Wan*, andXinghong Zhao*. "Mucoadhesive chitosan-catechol as an efficient vaccine delivery system for intranasal immunization."International Journal of Biological Macromolecules,2024, 133008.(IF = 8.2,最后通讯作者)
[4] Yumeng Wang#,Xinghong Zhao#, Xingjian Zhou#, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao*, Keqing Shi*, Yong Liu*, Yuanfeng Li*, and Linqi Shi. "A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing."Journal of Controlled Release,2024, 368:740-755.(IF = 10.8,共同第一作者)
[5] Hongping Wan#,*, Kai Deng#, Zhengqun Huang#, Yunhan Yang, Bo Jing, Yumei Feng, Yuanfeng Li, Yong Liu, Mingqin Liu, andXinghong Zhao*. "Pathogen-mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Iimmunization."Advanced Healthcare Materials,2024, 2401120.(IF = 10,最后通讯作者)
[6]Xinghong Zhao#,*, Xinyi Zhong#, Shinong Yang#, Kai Deng, Lu Liu, Xu Song, Yuanfeng Zou, Lixia Li, Xun Zhou, Renyong Jia, Juchun Lin, Huaqiao Tang, Gang Ye, Jianqing Yang, Shan Zhao, Yifei Lang, Hongping Wan*, Zhongqiong Yin*, and Oscar P. Kuipers. "Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine."Antimicrobial Agents and Chemotherapy,2023:e00010-23.(IF = 5.938,物理第一作者兼共同通讯作者)
[7]Xinghong Zhao, Zhongqiong Yin, Eefjan Breukink, Gert N. Moll, and Oscar P. Kuipers*. "An engineered double lipid II binding motifs-containing lantibiotic displays potent and selective antimicrobial activity against Enterococcus faecium."Antimicrobial Agents and Chemotherapy,2020, 64(6): e02050-19.(IF = 5.938,第一作者)
[8] Roderick Corstiaan Abraham Versloot, Patricia Arias-Orozco, Matthijs Jonathan Tadema, Florian Leonardus Rudolfus Lucas,Xinghong Zhao, Siewert J. Marrink, Oscar Paul Kuipers, and Giovanni Maglia*. "Seeing the Invisibles: Detection of Peptide Enantiomers, Diastereomers, and Isobaric Ring Formation in Lanthipeptides Using Nanopores."Journal of the American Chemical Society,2023, 145(33):18355-18365.(IF = 15)
[9]Xinghong Zhao, and Oscar P. Kuipers*. "Nisin-and ripcin-derived hybrid lanthipeptides display selective antimicrobial activity against Staphylococcus aureus."ACS Synthetic Biology,2021, 10(7): 1703-1714.(IF = 5.249,第一作者)
[10]Xinghong Zhao, and Oscar P. Kuipers*. "Synthesis of silver-nisin nanoparticles with low cytotoxicity as antimicrobials against biofilm-forming pathogens"Colloids and Surfaces B: Biointerfaces,2021, 206: 111965.(IF = 5.999,第一作者)
◆指导学生
现指导在读硕士生5名、本科生14名。