倪学勤 更新日期：2023-03-21
倪学勤,女,1968年出生,博士导师
工作单位 动物医学院
电子邮箱 xueqinni@foxmail.com
招生专业 【博士】:090602预防兽医学095200兽医,【学硕】:090602预防兽医学，【专硕】:095200兽医
◆个人简历
四川农业大学动物医学院动物微生态研究中心主任，四川省学术与技术带头人，中国畜牧兽医学会动物微生态学分会理事长，中国畜牧兽医学会动物福利与健康养殖分会常务理事，四川省兽医协会常务理事，国内外多个学术期刊编委和审稿专家。长期致力于动物微生态学的教学和基础研究工作，主要开展动物肠道微生物分子演替、微生态制剂作用机理及特效微生态制剂的研究和开发。先后主持和参加国家和省部级课题等20余项，主持获得省部级科技成果二等奖1项，参与获得二等奖1项，副主编、参编专著（教材）6部，在国内外重要学术期刊发表论文200余篇，申请获得国家专利10余个。
◆工作经历
1.2014/11－至今，中国畜牧兽医学会动物微生态分会，理事长
2.2010/01－至今，四川农业大学，动物医学院，教授，博士生导师
3.2008/5－2014/10，中国畜牧兽医学会动物微生态分会，副理事长
4.2006/4－2007/4，Food Research Program, Agriculture and Agri-food Canada，访问学者
5.2002/11－2008/5，中国畜牧兽医学会动物微生态分会，秘书长
6.2000/1－2009/12，四川农业大学，动物医学院，副教授，硕士生导师
7.1998/11－2002/11，中国畜牧兽医学会动物微生态分会，副秘书长
8.1995/1－1999/12，四川农业大学，动物医学院，讲师
9.1993/7－1994/12，四川农业大学，动物医学院，助教
◆教育经历
1994/09－1998/12，南京农业大学，动物医学院预防兽医学系，博士，导师：蔡宝祥
1990/09－1993/06，四川农业大学，动物医学院预防兽医学系，硕士，导师：何明清
1986/09－1990/06，四川农业大学，兽医系兽医卫生检验专业，学士
◆获奖荣誉
1.畜禽肠道健康合生元制品创新技术及产业化，2018年山东省科技进步奖，二等，排名第一
2.猪用新型产乳酸芽孢杆菌合生元饲料添加剂开发与应用，2019年度重庆市科技进步奖，二等，排名第十
◆社会、学会及学术兼职
中国畜牧兽医学会动物微生态分会理事长；
中国畜牧兽医学会动物福利与健康养殖分会常务理事；
四川省兽医协会常务理事；
中国畜牧兽医学会理事。
◆研究领域
（1）利用基因组和代谢组技术研究动物消化道疾病发生发展过程中微生物群落的结构、功能和相互作用；
（2）利用多组学技术研究动物体内微生物的结构和功能,尤其是消化道微生物生态学；
（3）高效益生菌研制及益生菌参与营养代谢、免疫调控的作用机制。
◆科研项目
1.国家自然科学基金面上项目32270561（202301-202612）：基于黏附效应研究大熊猫源益生菌对大肠杆菌诱发肠上皮细胞自噬AMPK/mTOR/ULK1通路的干预机制
2.青岛市生物制造行业智库联合基金QDSWZK202112（202109-202202）：仔猪腹泻病新型靶向微生态制剂创制
3.四川省科技厅国际合作项目2021YFH0097（202104-202303）：益生菌预防高氟摄入引起记忆损伤的机制研究
4.四川省科技计划 (应用基础研究) 2021YJ0166（202104-202303）：菌-肠-脑轴对精神分裂症康复的调控作用及分子机制研究
5.国家自然科学基金面上项目31970503（202001-202312）：大熊猫源植物乳杆菌对菌群源化小鼠肠道炎症的预防与治疗机制研究
6.四川省科技厅国际合作项目2019YFH0060 (201901-202012)：宿主和饮食塑造疣猴亚科动物特征性肠道微生物的研究
7.四川省科技厅国际合作项目2018HH0103 (201801-201912)：益生菌调控亚临床坏死性肠炎肉鸡肠肝循环的分子机制
8.成都大熊猫繁育研究基金会项目，CPF2017-04（201801-202112），临床死亡金丝猴等几种灵长类动物胃肠道微生物宏基因组与代谢的研究
9.国家自然科学基金面上项目31672318（201701-201812）：野生和圈养川金丝猴肠道菌群季节动态及功能研究
10.成都市科技局农业技术研发项目2015-NY02-00295-NC（201601-201912），黄曲霉毒素高效降解益生菌的定向筛选与应用研究
◆发表论文
近3年发表的代表性论文：
1.Baoxing Gan#, Ning Sun#, Jing Lai#, Zhiqiang Wan, Lianxin Li, Yanyan Wang, Yan Zeng, Dong Zeng, Kangcheng Pan, Jing Fang, Gang Shu, Hesong Wang, Jinge Xin*, Xueqin Ni*. Dynamic Monitoring of Changes in Fecal Flora of Giant Pandas in Mice: Co-Occurrence Network Reconstruction. Microbiology Spectrum, DOI: https://doi.org/10.1128/spectrum.01991-22
2.曹东，辛金鸽，曾燕，倪学勤. 基于16S rRNA测序分析巴马小型猪性别与肠道微生物的关系，黑龙江畜牧兽医，2022, No.659(23) ：115-120+137-138
3.Ning Sun#, Bin Zhu#, Jinge Xin#, Lianxin Li#, Baoxing Gan, Xi Cao, Jing Fang, Kangcheng Pan, Bo Jing, Yan Zeng, Cheng Lv, Ling Zhao, Dong Zeng, Peng Xu*, Hesong Wang* and Xueqin Ni*. Psychoactive effects of Lactobacillus johnsonii BS15 on preventing memory dysfunction induced by acute ethanol exposure through modulating intestinal microenvironment and improving alcohol metabolic level. Frontiers in Microbiology(Front Microbiol), 2022, 13(847468) doi: 10.3389/fmicb.2022.847468 (发表时间：2022.04.10) (分区：2区；IF：6.064) Top
4.Jie Wang#, Bin Wen#, Yan Zeng, Hesong Wang, Wei Zhao, Yi Zhou, Lei Liu, Ping Wang, Kangcheng Pan, Bo Jing, Xueqin Ni*, Dong Zeng*. Assessment the role of some Bacillus strains in improvement rex rabbits resistance against ETEC challenge, Microbial Pathogenesis(Microbial Pathogenesis), 2022, 165(105477) doi: 10.1016/j.micpath.2022.105 477 (发表时间：2022.03.09) (分区：3区；IF：3.848)
5.Ying Zhao#, Yan Zeng#, Dong Zeng, Hesong Wang, Ning Sun, Jinge Xin, Mengjia Zhou, Hanbo Yang, Lei Lei, Hongli Ling, Abdul Khalique, Danish Sharafat, Baoxing Gan, Zhiqiang Wan, Zhipeng Yao, Jing Fang, Kangcheng Pan, Gang Shu, Jing Bo, Dongmei Zhang, Xueqin Ni*. Dietary probiotic supplementation suppresses subclinical necrotic enteritis in broiler chickens in a microbiota-dependent manner. Frontiers in Immunology(Front Immunol), 2022, 13(855426) doi: 10.3389/fimmu.2022.855426 (发表时间：2022.03.18) (分区：2区；IF：8.786)
6.Jie Wang#, Yang Pu#, Yan Zeng, Yingyi Chen, Wei Zhao, Lili Niu, Benhao Chen, Zihan Yang, Liqian Wu, Kangcheng Pan, Bo Jing, Dong Zeng*, Xueqin Ni*. Multi-functional Potential of Five Lactic Acid Bacteria Strains Derived from Giant Panda (Ailuropoda melanoleuca). Probiotics and Antimicrobial Proteins(Probiotics Antimicro), 2022, PMID：35000110 doi：10.1007/s12602-021-09881-6 (发表时间：2022.01.09) (分区：2区；IF：5.265)
7.Lingling Liu#, Ran Sui, Lianxin Li, Lin Zhang, Dong Zeng, Xueqin Ni* and Jinghui Sun*. Light Activates Cdc42-Mediated Needle-Shaped Filopodia Formation via the Integration of Small GTPases. Cellular and Molecular Bioengineering, 2022, doi: 10.1007/s12195-022-00743-x (发表时间：2022.10.06)
8.Zhiqiang Wan#, Xufei Zhang#, Xianhao Jia#, Yuhua Qin, Ning Sun, Jinge Xin, Yan Zeng, Bo Jing, Jing Fang, Kangcheng Pan, Dong Zeng, Yang Bai, Hesong Wang*, Hailin Ma* and Xueqin Ni*. Lactobacillus johnsonii YH1136 plays a protective role against endogenous pathogenic bacteria induced intestinal dysfunction by reconstructing gut microbiota in mice exposed at high altitude. Frontiers in Immunology(Front Immunol), 2022, doi: 10.3389/fim mu.2022.1007737 (发表时间：2022.10.10) (分区：2区；IF：8.786) Top
9.Weijie Li, Jianzhen Li, Xixi Dai, Minggang Liu,Abdul Khalique, Zhenghua Wang, Yan Zeng,Dongmei Zhang, Xueqin Ni, Dong Zeng, Bo Jing, Kangcheng Pan*. Surface Display of porcinecircovirus type 2 antigen protein cap on the spores of bacillus subtilis 168: An effective mucosal vaccine candidate. Frontiers in Immunology(Front Immunol), 2022, 13:1007202. doi: 10.3389/fimmu.2022.1007202
10.Zhihua Ren#, Samuel Kumi Okyere#, Lei Xie, Juan Wen, Jiayi Wang, Zhengli Chen, Xueqin Ni, Junliang Deng and Yanchun Hu*. Oral Administration of Bacillus toyonensis Strain SAU-20 Improves Insulin Resistance and Ameliorates Hepatic Steatosis in Type 2 Diabetic Mice. Frontiers in Immunology(Front Immunol), 2022, 13(837237) doi: 10.3389/fimmu.202 2.837237 (发表时间：2022.02.15) (分区：2区； IF：8.786) Top
11.Dan Xiao#, Zhenhua Wang#, Xixi Dai#, Yuanwei Hu, Maiyi Zhong, Lvchen Xiong, Chuanheng Jiang, Abdul Khalique, Xueqin Ni, Dong Zeng, Dongmei Zhang, Yan Zeng, Kangcheng Pan*. Effects of Bacillus methylotrophicus SY200 Supplementation on Growth Performance, Antioxidant Status, Intestinal Morphology, and Immune Function in Broiler Chickens. Probiotics and Antimicrobial Proteins( Probiotics Antimicro), 2022, PMID: 35150396 doi: 10.1007/s12602-022-09924-6 (发表时间：2022.02.12) (分区：2区；IF：5.265)
12.Y. Zeng#, Y. Pu#, L.L. Niu#, J.B. Deng, D. Zeng, K.R. Amato, Y. Li, Y. Zhou, Y.C. Lin, J. Wang, L.Q. Wu, B.H. Chen, K.C. Pan, B. Jing, X.Q. Ni*. Comparison of gastrointestinal microbiota in golden snub-nosed monkey (Rhinopithecus roxellanae), green monkey (Chlorocebus aethiops sabaeus), and ring-tailed Lemur (Lemur catta) by high throughput sequencing. Global Ecology and Conservation(Glob Ecol Conserv), 2022, 33(e01946) doi: 10.1016/j.gecco.2021.e01946 (发表时间：2022.01) (分区：3区；IF：3.969)
13.Yi Zhou#, Ling Duan#, Yan Zeng#, Lili Niu, Yang Pu, Jonathan P. Jacobs, Candace Chang, Jie Wang, Abdul Khalique, Kangcheng Pan, Jing Fang, Jing Bo, Dong Zeng*, Xueqin Ni*. The panda-derived Lactobacillus plantarum G201683 alleviates the inflammatory response in DSS-induced panda microbiota-associated mice. Frontiers in Immunology(Front Immunol), 2021, 12(747045) doi: 10.3389/fimmu.2021.747045 (发表时间：2021.12.08) (分区：2区； IF：8.786) Top
14.Jinge Xin#, Ning Sun#, Hesong Wang#, Hailin Ma#, Bangyuan Wu, Lianxin Li, Yanyan Wang, Haonan Huang, Dong Zeng, Xiuquan Bai, Ali Chen, Shenhai Gong, Xueqin Ni* and Yang Bai*. Preventive effects of Lactobacillus johnsonii on the renal injury of mice induced by high fluoride exposure: Insights from colonic microbiota and co-occurrence network analysis. Ecotoxicology and Environmental Safety(Ecotox Environ Safe), 2021, PMID:34826 728 doi: 10.1016/j.ecoenv.2021.113006 (发表时间：2021.11.23) (分区：大类2区；小类1区；IF：7.129) Top
15.Ning Sun#, Yan Xue#, Siyi Wei#, Bangyuan Wu, Hesong Wang, Dong Zeng, Ying Zhao, Abdul Khalique, Kangcheng Pan, Yan Zeng, Gang Shu, Bo Jing, Xueqin Ni*. Compound Probiotics Improve Body Growth Performance by Enhancing Intestinal Development of Broilers with Subclinical Necrotic Enteritis. Probiotics and Antimicrobial Proteins(Probiotics Antimicro), 2021, PMID: 34735679 doi: 10.1007/s12602-021-09867-4 (发表时间：2021.11.04) (分区：2区；IF：5.265)
16.Zhiqiang Wan#, Ning Sun#, Min Luo#, Baoxing Gan, Zhipeng Yao, Xi Cao, Hesong Wang, Kangcheng Pan, Gang Shu, Yan Zeng, Dong Zeng*, Xueqin Ni*. Promotion of Egg Production Rate and Quality Using Limosilactobacillus oris BSLO 1801, a Potential Probiotic Screened from Feces of Laying Hens with Higher Egg Productive Performance. Probiotics and Antimicrobial Proteins(Probiotics Antimicro), 2021, PMID: 34697775 doi: 10.1007/s12602-021-09856-7 (发表时间：2021. 10. 25) (分区：2区；IF：5.265)
17.Jinge Xin#，Hesong Wang#，Ning Sun，Shamsuddin Bughio，Dong Zeng，Lianxin Li，Yanyan Wang，Abdul Khalique，Yan Zeng， Kangcheng Pan，Bo Jing，Hailin Ma，Yang Bai*，Xueqin Ni*. Probiotic alleviate fluoride-induced memory impairment by reconstructing gut microbiota in mice. Ecotoxicology and Environmental Safety(Ecotox Environ Safe), 2021, 215(112108) doi: org/10.1016/j.ecoenv.2021.112108 (发表时间：2021.3.30) (分区：大类：2区；小类：1区；IF：7.129) Top
18.倪学勤，原籍菌在肉鸡饲料中的研究与应用进展，饲料工业，2021，42（5）：1-4
19.Ying Zhao#, Yan Zeng, Dong Zeng, Hesong Wang, Mengjia Zhou, Ning Sun, Jinge Xin, Abdul Khalique, Danish Sharafat Rajput, Kangcheng Pan, Gang Shu, Bo Jing, Xueqin Ni*. Probiotics and microRNA: their roles in the host-microbe interactions. Frontiers in Microbiology(Front Microbiol), 2021, 11(604462) doi ：10.3389/fmicb.2020.604462 (发表时间：2021.01.14) (分区：2区；IF：6.064) Top
一作&通讯2020
20.Danish Sharafat Rajput#，Dong Zeng#，Abdul Khalique#，Samia Sharafat，Hesong Wang，Ying Zhao，Ning Sun，Xueqin Ni*. Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics. AMB Express(AMB Express), 2020, 10(220) doi: 10.1186/s13568-020-01153-w (发表时间：2020.12.17) (分区：3区；IF：4.162)
21.Yi Zhou#, Xueqin Ni#, Ling Duan#, Lili Niu, Qian Liu, Yan Zeng, Qiang Wang, Jie Wang, Abdul Khalique, Kangcheng Pan, Bo Jing and Dong Zeng*. Lactobacillus plantarum BSGP201683 improves the intestinal barrier of giant panda microbiota-associated mouse infected by Enterotoxigenic Escherichia coli K88. Probiotics and Antimicrobial Proteins(Probiotics Antimicro), 2020, 13(3): 664-676 doi: org/10.1007/s12602-020-09722-y (发表时间：2020.11.14) (分区：2区；IF：5.265)
22.Jinge Xin*, Dong Zeng*, Hesong Wang#, Ning Sun, Abdul Khalique, Ying Zhao, Liqian Wu, Kangcheng Pan, Bo Jing, Xueqin Ni#. Lactobacillus johnsonii BS15 improves intestinal environment against fluoride-induced memory impairment in mice—a study based on the gut–brain axis hypothesis. PeerJ, 2020, 8(e10125) doi: 10.7717/peerj.10125 (发表时间：2020.10.07) (分区：3区；IF：3.061 )
23.Ying Zhao#, Dong Zeng#, Hesong Wang, Ning Sun, Jinge Xin, Hanbo Yang, Lei Lei, Abdul Khalique, Danish Sharafat Rajput, Kangcheng Pan, Gang Shu, Bo Jing, Xueqin Ni*. Analysis of miRNA Expression in the Ileum of Broiler Chickens During Bacillus licheniformis H2 Supplementation Against Subclinical Necrotic Enteritis. Probiotics and Antimicrobial Proteins(Probiotics Antimicro), 2020, 13(356-366) doi: 10.1007/s12602-020-09709-9 (发表时间：2020.09.25) (分区：2区；IF：5.265)
24.刘磊，曾东，潘康成，倪学勤. 益生菌调控肠道闭锁蛋白表达的机制，动物营养学报，2020，32（4）：1526-1535，10.3969/j.issn.1006-267X.2020.04.008
25.Jie Wang#, Xueqin Ni#, Bin Wen#, Yi Zhou, Lei Liu, Yan Zeng, Wei Zhao, Abdul Khalique, Ping Wang, Kangcheng Pan, Zhiju Yu, Bo Jing, Hanzhong Liu, Dong Zeng*. Bacillus strains improve growth performance via enhancing digestive function and anti-disease ability in young and weaning rex rabbits. Applied Microbiology and Biotechnology(Appl Microbiol Biol), 2020, PMID: 32193576 doi: 10.1007/s00253-020-10536-9 (发表时间：2020.03.19) (分区：3区；IF：5.56)
26.Abdul Khalique#, Dong Zeng#, Muhammad Shoaib#, Hesong Wang, Xiaodan Qing, Danish Sharafat Rajput, Kangcheng Pan, Xueqin Ni*. Probiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultry. AMB Express, 2020, 10(50) doi: 10.1186/s13568-020-00989-6 (发表时间：2020.03.14) (分区：3区；IF：4.126)
27.Ning Sun#, Xueqin Ni#, Hesong Wang*, Jinge Xin, Ying Zhao, Kangcheng Pan, Bo Jing, Dong Zeng*. Probiotic Lactobacillus johnsonii BS15 Prevents Memory Dysfunction Induced by Chronic High-Fluorine Intake through Modulating Intestinal Environment and Improving Gut Development. Probiotics and Antimicrobial Proteins(Probiotics Antimicro), 2020, PMID: 32166711 doi: 10.1007/s12602-020-09644-9 (发表时间：2020.03.12) (分区：2区；IF：5.265)
◆专著教材
授权的发明专利：
1.倪学勤，曾东，罗慧，周梦佳，潘康成，景波，李涛，王剑，马源晨，祝辉.枯草芽孢杆菌BS01发酵灵芝孢子粉的制备及其在改善睡眠中的应用，CN201410152501.1
2.倪学勤，曾东，辛金鸽，曾燕，王鹤松，祝辉，周梦佳，李涛，潘康成，景波.约氏乳酸杆菌BS15及其在预防和治疗非酒精性脂肪肝中的应用，ZL 201410156594.5，2016.4.13
3.曾东，倪学勤，闫冰，周梦佳，曾燕，李倩，李涛.枯草芽孢杆菌BS01与灵芝孢子粉的组合物在改善睡眠中的应用，CN201310301090.3
4.舒刚，赵小玲，汪开毓，朱庆，倪学勤，曾东，符华林，范巧佳，曾燕，一种利用益生菌和中药饲养优质鸡公鸡的方法及其所用饲料，ZL2013103167774


专著教材：
1.副主编 《动物微生态》 高等院校素质教育教材，四川科学技术出版社2004.02出版
2.副主编《动物微生态研究进展》中国农业大学出版社，2000.09出版