◆科研项目
近5年科研项目如下:
1.四川省科学技术厅, 国际港澳台科技创新合作项目,四川地区优势血清型猪胸膜肺炎放线杆菌调查及其亚单位疫苗创制(2023YFH0047), 2023.01-2024.12, 30万元,在研项目,主持;
2.四川省科学技术厅, 四川省“十四五”川猪重大科技专项, 2021ZDZX0010, 川猪重大疫病防控新技术新产品创制, 2021-2026, 70万元, 在研, 主研;
3.国家自然科学基金面上项目,JEV E-I176R位点突变介导其神经毒力减弱的感染机理(31972722), 2020.1-2023.12,56万,已结题,主研;
4.国家重点研发计划,重要神经嗜性人兽共患病免疫与致病机制研究(2016YFD0500403),2016-2020年,140万,已结题,主研;
5.四川省教育厅重点项目,乙脑病毒E蛋白外膜囊泡疫苗对小鼠免疫保护效果研究(18ZA0378) ,2018-01-01到2020-12-31,2万,已结题,主持。
◆发表论文
近年来代表性论文:
1. Luo, S.-Q., Cao, S.-J., Zhao, Q. CRISPR/Cas9-Mediated Knockout of the HuR Gene in U251 Cell Inhibits Japanese Encephalitis Virus Replication [J]. Microorganisms, 2024, 12, 314. (SCI, IF=4.5)
2. 戴世馨,赵勤,曹三杰等.低浓度猪链球菌溶血素诱导猪肾细胞凋亡方式研究[J]. 农业生物技术学报,2024, 32 (2):355-366. (CSCD)
3. Xiao Hang, Zhao Qin,Yuan Jianlin et al. IFN-γ promotes PANoptosis in Pasteurella multocida toxin-induced pneumonia in mice.[J] .Vet Microbiol, 2023, 285: 109848. (SCI, IF=3.246)
4.Xu K , Zhao Q , Jiang H Z , et al. Molecular and functional characterization of HtrA protein in Actinobacillus pleuropneumoniae[J]. Veterinary Microbiology, 2021,(12):109058. (SCI, IF=3.030)
5. Zhao Qin, Yang Zhao-Si, Yinlong Wu.et al. Acute oral toxicity test and assessment of combined toxicity of cadmium and aflatoxin B1 in kunming mice [J]. Food Chem. Toxicol., 2019, 131: 110577. (SCI, IF=3.977)
6. Cao Yu-Qin,Yuan Lei, Zhao Qin et al.Hsp40 Protein DNAJB6 Interacts with Viral NS3 and Inhibits the Replication of the Japanese Encephalitis Virus[J]. International Journal of Molecular Sciences, 2019, 20(22):1-18. (SCI, IF= 3.687)
7. 李莹馨,原茜,赵勤等.魔芋葡甘露聚糖对镉所致的LO2细胞毒性损伤的影响[J]. 西南农业学报, 2019, 32(8): 1918-1923. (CSCD)
8. Xu K , Zhao Q , Wen X , et al. A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model[J]. Plos One, 2018, 13(1): 1-25. e0191286. (SCI, IF=2.806)
9. Zhang Fei, Zhao Qin, Quan Keji. et al. Galactose-1-phosphate uridyltransferase (GalT), an in vivo-induced antigen of Actinobacillus pleuropneumoniae serovar 5b strain L20, provided immunoprotection against serovar 1 strain MS71[J]. PLoS ONE, 2018, 13: e0198207. (SCI, IF=2.806)
10. Zhang Fei, Zhao Qin, Tian Jin, et al. Effective Pro-Inflammatory Induced Activity of GALT, a Conserved Antigen in A. Pleuropneumoniae, Improves the Cytokines Secretion of Macrophage via p38, ERK1/2 and JNK MAPKs Signal Pathway [J]. Frontiers in Cellular and Infection Microbiology, 2018, 8: 337. (SCI, IF=3.520)