蔡易 更新日期:2024-10-29
蔡易,男,1982年出生,博士导师
工作单位 生命科学学院
电子邮箱 yicai@sicau.edu.cn
招生专业 【博士】:071010生物化学与分子生物学,【学硕】:071010生物化学与分子生物学,【专硕】:086000生物与医药
◆个人简历
蔡易,男,教授,博士生导师。2010年于香港中文大学获得博士学位,2011-2014年分别于香港中文大学与哈佛医学院从事博士后研究,2014年进入四川农业大学从事教学科研工作。从事科研工作以来,在《Plant Cell》,《Trends in Plant Science》,《Plant Physiology》,《Journal of Experimental Botany》,《Journal of Agricultural and Food Chemistry》等SCI期刊上发表收录论文40余篇,先后主持国家人力资源和社会保障部“高层次留学人才回国工作资助”(该年度四川省唯一获得人选)、四川省“天府峨眉计划创业领军人才”、霍英东基金会“青年教师基金”等省部级项目,获教育部自然科学奖二等奖一项。
◆工作经历
2014.6-至今 四川农业大学,生命科学学院,教授,博士生导师
2013.4-2014.5 哈佛医学院,遗传学系,博士后
2010.11-2013.3 香港中文大学,生命科学学院,博士后
◆教育经历
2006.8-2010.10 香港中文大学,生物学,博士
2002.9-2005.6 南开大学,微生物学,硕士
1998.9-2002.6 南开大学,微生物学,学士
◆获奖荣誉
教育部自然科学奖二等奖一项(排名7/7)
◆社会、学会及学术兼职
1. 四川农业大学校学术委员会委员(2017.04-至今)。
2. 中国农业生物化学与分子生物学学会副秘书长(2023.08-至今)。
3. 四川省科技青年联合会常务理事(2018.12-至今)。
4. 四川省植物病理学会理事(2018.05-至今)。
5. 中国农业生物化学与分子生物学学会青年委员会主任(2018.08-2023.07)。
◆研究领域
植物新型小肽信号及其转导机制的研究
◆科研项目
5、成都绿信诺生物科技有限公司,校企共建“四川农业大学生命科学学院肽灵生物农药研究中心”(2021-2026,主持)。
4、霍英东教育基金会,青年教师基金,重组类受体激酶增强植物抗病力(2016-2018,主持)。
3、四川省教育厅,高校科研创新团队,植物发育与抗病创新团队(2016-2018,主持)。
2、四川省科技厅、杰出青年基金,植物类受体激酶对抗病的功能性研究(2016-2018,主持)。
1、中国人力资源和社会保障部,高层次留学人才回国工作资助(2015-2017,主持)。
◆发表论文
25. Yao H.*, Li Q.*, Zhao Y., Shen J., Cai Y.# Full length flagellin from Pseudomonas aeruginosa prolongs the persistence of immune activation than the core flg22 peptide, in preparation.
24. Yu X.*, Wan S.*, Xu N., Huang Z., Li J., Shi K., Shen J., Shao X., Li J., Lu Y.#, Cai Y.# BPAST: a sequence matching algorithm for peptides and polynucleotides, in preparation.
23. Huang Y.*, Li L.*, Shen X., Li Y., He Z., Liu J., Shen J., Cai Y.# The immunoprotein engineered with tandem recombination of multiple PAMPs endows Solanaceae crops with broad-spectrum resistance, under review.
22. Wan S.*, Yu X.*, Wang P., Liu J., Huang Y., Shi K., Shen J., Cai Y.# Phytocytokines LAND2 peptide confers systemic resistance with broad-spectrum activity, under review.
21. Man X.*, You H.*, Cheng Z.*, Li J., Yao D., Wang H., Diao Z., Yu X., Wu W., Zhou C., Huang Y., Shen J., Zhuang X.#, and Cai Y.# (2024) The engineering and application of multiepitope recombinant proteins (MEPs) enhanced resistance to Botrytis cinerea in tomatoes, presenting a new paradigm in the creation of plant immune activators, under review.
20. Huang Y.*, Yuan Y.*, Yang R., Dai S., Zhou J., Guo J., Shen J., Lu Y., Liu Y.#, Cai Y.# (2024) A large-scale screening identifies receptor-like kinases with common features in kinase domains that are potentially related to disease resistance in plant, Front. Plant Sci., accepted.
19. Li J.*, Guo J.*, Hu Y., Cui J., Huang Y., Wang Y., Tang Y., Wu Q., Diao Z., Shen J., Cai Y.# (2024) Receptor cytoplasmic kinase SZE1 interacts with BAK1 and positively regulates the PTI signaling pathway. Physiol. Mol. Plant Pathol., 134:102415.
18. Wu W., Ali A., Shen J., Ren M., Cai Y.#, He L.# (2024) Cell penetrating peptide enhances the aphidicidal activity of spider venom-derived neurotoxin. Toxins, 16:358.
17. Yu X.*, Huang Z.*, Cheng Y., Hu K., Zhou Y., Yao H., Shen J., Huang Y., Zhuang X.#, Cai Y.# (2024) Comparative genomics screens identify a novel small secretory peptide, SlSolP12, which activates both local and systemic immune response in tomatoes and exhibits broad-spectrum activity. J. Agric. Food Chem., 72:18507-18519.
16. Li J.*, Huang Y., Yu X., Wu Q., Diao Z., Man X., You H., Shen J., Cai Y.# (2024) Identification and application of CLE peptides for drought-resistance in Solanaceae crops. J. Agric. Food Chem., 72:13869–13884.
15. Diao Z.*, Yang R.*, Wang Y., Cui J., Li J., Wu Q., Zhang Y., Yu X., Gong B., Huang Y., Yu G., Yao H., Guo J., Zhang H., Shen J., Gust A., Cai Y.# (2024) Functional screening of the Arabidopsis 2C protein phosphatases family identifies PP2C15 as a negative regulator of plant immunity by targeting BRI1-associated receptor kinase 1. Mol. Plant Pathol., 25:e13447.
14. Yu X.*, Wang H., Lei F., Li R., Yao H., Shen J., Ain N., Cai Y.# (2023) Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in Arabidopsis thaliana. Front. Plant Sci., 14:1208549.
13. Huang Y.*, Yang R.*, Luo H., Yang Y., Diao Z., Li J., Gong S., Yu G., Yao H., Zhang H., Cai Y.# (2023) Arabidopsis protein phosphatase PIA1 impairs plant drought tolerance by serving as a common negative regulator in ABA signaling pathway. Plants, 12:2176.
12. Huang Y.*, Cui J.*, Li M.*, Yang R., Hu Y., Yu X., Chen Y., Wu Q., Yao H., Yu G., Guo J., Zhang H., Wu S.#, Cai Y.# (2023) Conservation and divergence of flg22, pep1 and nlp20 in activation of immune response and inhibition of root development. Plant Sci., 331:111686.
11. Huang Y.*#, Li J.*, Huang T.*, Bai X., Li Q., Gong Y., Hoy R., He Z., Liu J., Liao J., Yuan M., Ding C., Li X., Cai Y.# (2023) The homeostasis of R protein RPS2 is regulated negatively by the RING-type E3 ligase MUSE16. J. Exp. Bot., 74:2160-2172.
10. Cui J.*, Hu Y., Huang Y., Guo J., Xie X., Zhang H., Cai Y.# (2022) Loss of function mutation of IOS1 in Arabidopsis is more sensitive to salt stress. Plant Mol. Biol. Rep., 40:68-80.
9. Huang Y.*, Li T.*, Xu T., Tang Z., Guo J., Cai Y.# (2020) Multiple Xanthomonas campestris pv. campestris 8004 type III effectors inhibit immunity induced by flg22. Planta, 252:88.
8. Xie X.*, He Z.*, Chen N., Tang Z., Wang Q., Cai Y.# (2019) The roles of environmental factors in regulation of oxidative stress in plant. BioMed Res. Int., 2019:9732325. (ESI高被引论文)
7. Guo J.*, Miao Y., Cai Y.# (2017) Analysis of membrane protein topology in the plant secretory pathway. Methods Mol. Biol., 1662:87-95.
6. Wang X.*, Cai Y.*, Gao C., Zhuang X. and Jiang L.# (2014) Trans-Golgi Network-Located AP1 Gamma Adaptins Mediate Dileucine Motif-Directed Vacuolar Targeting in Arabidopsis. Plant Cell, 26:4102-4118.
5. Cai, Y.*, Zhuang X.*, Gao C.*, Wang X.* and Jiang L.# (2014) A Systematic Analysis of Arabidopsis Endosomal Sorting Complex Required for Transport III (ESCRT-III) Complex in Regulating Prevacuolar Compartment-mediated Protein Sorting and Plant Development. Plant Physiol., 165:1328-1343.
4. Gao C.*, Cai Y.*, Wang Y., Kang B., Aniento F., Robinson D.G., Jiang L.# (2014) Retention Mechanisms for ER and Golgi Membrane Proteins. Trends Plant Sci., 19:508-515.
3. Cai Y.*, Zhuang X.*, Wang J., Wang H., Lam S.K., Gao C., Wang X. and Jiang L.# (2012) Vacuolar degradation of two plasma membrane proteins, AtLRR84A and OsSCAMP1, is cargo ubiquitination-independent and prevacuolar compartment-mediated in plant cells. Traffic, 13:1023-1040.
2. Cai Y.*, Jia T., Lam S.K., Ding Y., Gao C., San M.W., Pimpl P. and Jiang L.# (2011) Multiple cytosolic and transmembrane determinants are required for the trafficking of SCAMP1 via an ER-Golgi-TGN-PM pathway. Plant J., 65:882-896.
1. Lam S.K.*, Cai Y.*, Tse Y.C., Wang J., Law A.H., Pimpl P., Chan H.Y., Xia J., and Jiang L.# (2009) BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells. Plant J., 60:865-881.
完整发表论文列表:https://www.researchgate.net/profile/Yi-Cai-48/publications; https://orcid.org/0000-0002-9152-9211
◆教学活动
现承担《基因工程》本科生课程,曾承担《生命组学进展》,《生命科学进展》两门研究生课程。
◆指导学生
课题组现有硕博士研究生20余人,研究方向为小肽的基础理论及产业化研究,小肽为生命科学领域的明星分子,其作用机制的研究为生物学基础理论研究的前沿领域,在生物医药、食品和生物农药领域具有广阔的应用前景,欢迎有志于该领域研究的同学报考硕博士研究生。
◆我的团队
本人为“小肽农药分子设计与作用机制”团队负责人,团队成员4人。团队以国家“两减”战略为导向,开发高效安全具备不同功能的靶向小肽农药,建立以小肽为核心的植物病虫害绿色防控理论和应用体系,以期降低化学农药的使用量,保障粮食安全、生命健康和生态平衡。本研究组利用计算生物学、分子生物学、组学以及合成生物学技术围绕以下两个方向开展研究:一、调控植物抗病、抗逆和发育的小肽信号挖掘及机理阐释。二、新型小肽类生物农药的研制。团队研究成果发表于J. Exp. Bot.,J. Agric. Food Chem.,Mol. Plant Pathol.等期刊。团队主持国家自然科学基金项目3项、霍英东教育基金会青年教师基金1项、四川省杰出青年基金等省部级科研项目10余项,申请中美发明专利6项,并初步实现成果转化。课题组常年招聘科研助理、博士后、青年研究员和青年教师,欢迎具有计算生物学、合成生物学、分子生物学、植物保护等专业背景的硕博士研究生和博士后联系。