卜贵鲜 更新日期:2024-03-19
卜贵鲜,男,1987年出生,学硕导师
工作单位 生命科学学院
电子邮箱 askjiushang02@126.com; Guixianbu@sicau.edu.cn
招生专业 【学硕】:071009细胞生物学,【专硕】:086000生物与医药
◆个人简历
细胞生物学博士,副教授,硕士生导师,四川省第十四批学术技术带头人后备人选。主要围绕动物体内“下丘脑-垂体-靶器官”轴开展分子内分泌与生理学研究,主要方向包括:(1)动物应激反应与繁殖活动的分子与细胞调控机制;(2)应激对经济动物生产性能的影响及其机理。目前已在内分泌领域权威杂志发表SCI论文多篇,2016年发表于《Endocrinology》的成果被美国阿肯色大学学者专题撰文进行评论,认为该结果为研究神经肽B/W的功能开启了一扇新的大门。2022年,与四川大学合作发现神经肽W(NPW)可以在垂体水平抑制家鸡应激轴活性,成为脊椎动物中第一个被鉴定到的应激轴生理性抑制因子(CRIF),为争议30年的CRIF存在形式揭开了神秘的面纱。
◆工作经历
2019.12-至今 四川农业大学生命科学学院 副教授
2016.07-2019.12 四川农业大学生命科学学院 讲师
◆教育经历
2013.09-2016.06 四川大学生命科学学院 攻读细胞生物学博士
2010.09-2013.06 四川大学生命科学学院 攻读细胞生物学硕士
2006.09-2010.06 四川农业大学生命科学与理学院(现生命科学学院) 生物科学本科在读
◆获奖荣誉
(1)2013年 “唐立新奖学金” 唐立新教育基金会
(2)2014年 “博士研究生国家奖学金” 教育部
(3)2022年 四川省第十四批学术技术带头人后备人选(自然科学类)
◆社会、学会及学术兼职
Frontiers in Endocrinology客座副主编
中国细胞生物学会会员
四川省科技青年联合会会员
CSS创享俱乐部成员
◆研究领域
分子内分泌与生理学
◆科研项目
(1)国家自然科学基金面上项目,32072705,孕酮调控NPBWR2介导家鸡应激轴的抑制效应及其作用机制研究,2021.01-2024.12,59万,主持
(2)四川省科技厅应用基础研究项目,2020YJ0127,神经肽W作为家鸡应激轴生理性抑制因子的潜能研究,2020.01-2022.12,10万,主持
(3)国家自然科学基金青年科学基金项目,31702111,神经肽 W(NPW)对家鸡应激轴的抑制效应研究,2018.01-2020.12,25万,主持
(4)四川省教育厅青年基金项目,18ZB0462,新型促肾上腺皮质激素释放激素类似肽在家鸡垂体中的功能探究,2018.01-2020.12,1万,主持
(5)国家自然科学基金面上项目,31870355,青藏高原东南缘及邻近地区恒河猴及其肠道微生物的协同演化动态与机制研究,2019.01-2022.12,60万,主研
(6)国家自然科学基金面上项目,31572391,家鸡新型垂体激素CART肽的生成释放调节机制解析及其在卵巢中的作用初探,2016.01-2019.12,66万,主研
(7)国家自然科学基金面上项目,31472089,家鸡短链脂肪酸(SCFAs)受体基因功能鉴定及SCFAs在肠组织中的作用探究,2015.01-2018.12,86万,主研
(8)国家自然科学基金面上项目,31272436,EGFR及其配体在控制家鸡卵泡颗粒细胞增殖、分化、凋亡过程中的作用机理研究,2013.01-2016.12,80万,主研
(9)黑龙江省普通高等学校动物遗传育种与繁殖重点实验室开放课题,两种催乳素(PRL及PRL-L)与催乳素受体(PRLR)在家鸡中的作用机制探究,2012.01-2013.12,3万,主研
◆发表论文
(1)Ming Yang, Yu Ji, Tao Yong, Tuoyuan Liu, Shuai Yang, Shasha Guo, Fengyan Meng, Xingfa Han, Qiuxia Liang, Xiaohan Cao, Linyan Huang, Xiaogang Du, Anqi Huang, Fanli Kong, Xianyin Zeng, Guixian Bu. Corticosterone Stage-dependently Inhibits Progesterone Production Presumably via Impeding the cAMP-StAR Cascade in Granulosa Cells of Chicken Preovulatory Follicles, Poultry Science, 2023, 102(2): 102379 (通讯作者,IF 4.014)
(2)Guixian Bu, Ying Lin, Jianfeng Liu, Pan Yu, Tao Yong, Ming Yang, Linyan Huang, Xingfa Han, Xiaogang, Du, Fanli Kong, Anqi Huang, Xianyin Zeng, Fengyan Meng. Evidence for Progesterone Acting as an Inhibitor of Stress Axis via Stimulating Pituitary Neuropeptide B/W Receptor 2 (NPBWR2) Expression in Chickens. Journal of Steroid Biochemistry and Molecular Biology, 2023, 226: 106218 (第一作者,IF 5.011)
(3)Fengyan Meng, Yu Yu, Jinxuan Li, Xingfa Han, Xiaofang Du, Xiaohan Cao, Qiuxia Liang, Anqi Huang, Fanli Kong, Linyan Huang, Xianyin Zeng, Guixian Bu. Characterization of Spexin (SPX) in Chickens: Molecular Cloning, Functional Analysis, Tissue Expression and Its Involvement in Appetite Regulation. Poultry Science, 2023, 102(1): 102279 (通讯作者,IF 4.014)
(4)Meng Liu, Guixian Bu, Yiping Wan, Jiannan Zhang, Chunheng Mo, Juan Li, Yajun Wang. Evidence for Neuropeptide W Acting as a Physiological Corticotropin-releasing Inhibitory Factor (CRIF) in Male Chickens. Endocrinology, 2022, 163(7): 1-14 (共同第一作者, IF 5.051)
(5)Ming Yang, Chenchen Jin, Xinyue Cheng, Tuoyuan Liu, Yu Ji, Fengyan Meng, Xingfa Han, Qiuxia Liang, Xiaohan Cao, Linyan Huang, Xiaogang Du, Xianyin Zeng, Guixian Bu. Corticosterone Triggers Anti-proliferative and Apoptotic Effects, and Downregulates the ACVR1-SMAD1-ID3 Cascade in Chicken Ovarian Prehierarchical, but not Preovulatory Granulosa Cells. Molecular and Cellular Endocrinology. 2022, 552: 111675 (通讯作者, IF 4.369)
(6)Ming Yang, Ming Yang, Ying Lin, Fengyan Meng, Xiaogang Du, Xianyin Zeng, Guixian Bu. Characterization of Prolactin (PRL) and PRL Receptor (PRLR) in Chinese Soft-shelled Turtle: Molecular Identification, Ligand-receptor Interaction and Tissue Distribution. General and Comparative Endocrinology, 2022, 316: 113941 (封面论文,通讯作者, IF 3.255)
(7)Ming Yang, Ying Lin, Jie Fan, Yupin Yin, Pan Yu, Fengyan Meng, Xiaogang Du, Xingfa Han, Xiaohan Cao, Fanli Kong, Anqi Huang, Linyan Huang, Xianyin Zeng, Guixian Bu. Characterization of Growth Hormone (GH) in Chinese Soft-shelled Turtle: Molecular Identification, Capability in Activating GH Receptor and Tissue Distribution. Aquaculture Reports, 2020, 18: 100407 (通讯作者, IF 2.289)
(8)Guixian Bu, Lin Cui, Can Lv, Dongliang Lin, Long Huang, Zhengyang Li, Juan Li, Xianyin Zeng, Yajun Wang. Opioid Peptides and Their Receptors in Chickens: Structure, Functionality, and Tissue Distribution. Peptides, 2020, 128 (6): 170307 (第一作者, IF 2.843)
(9)Guixian Bu, Jie Fan, Ming Yang, Can Lv, Ying Lin, Jinxuan Li, Fengyan Meng, Xiaogang Du, Xianyin Zeng, Jiannan Zhang, Juan Li, Yajun Wang. Identification of a Novel Functional Corticotropin-Releasing Hormone (CRH2) in Chickens and Its Roles in Stimulating Pituitary TSHβ Expression and ACTH Secretion. Frontiers in Endocrinology, 2019, 10: 595 (第一作者, IF 3.644)
(10)Guixian Bu, Dongliang Lin, Lin Cui, Long Huang, Can Lv, Simiao Huang, Yiping Wan, Chao Fang, Juan Li, Yajun Wang. Characterization of Neuropeptide B (NPB), Neuropeptide W (NPW) and Their Receptors in Chickens: Evidence for NPW being a Novel Inhibitor of Pituitary Growth Hormone and Prolactin Secretion. Endocrinology, 2016, 157(9): 3562-3576 (评述论文,第一作者, IF 4.159)
Commented by Endocrinology: Opening a New Door: Neuropeptide W (NPW) Is a Novel Inhibitory Secretagogue for GH and Prolactin Acting via the Gi Protein-Coupled NPBWR2
(11)Guixian Bu, Xiaomeng Liang, Juan Li, Yajun Wang. Extra-pituitary Prolactin (PRL) and Prolactin-like Protein (PRL-L) in Chickens and Zebrafish. General and Comparative Endocrinology, 2015, 220 (1): 143-153 (第一作者, IF 2.667)
(12)Guixian Bu, Guian Huang, Hao Fu, Juan Li, Simiao Huang, Yajun Wang. Characterization of the Novel Duplicate PRLR at the Late-feathering K Locus in Lohmann Chickens. Journal of Molecular Endocrinology. 2013, 51(2): 261-276 (第一作者, IF 3.621)
(13)Guixian Bu, Crystal Ying Wang, Guoqing Cai, Frederick C. Leung, Min Xu, Hongning Wang, Guian Huang, Juan Li, Yajun Wang. Molecular Characterization of Prolactin Receptor (cPRLR) Gene in Chickens: Gene Structure, Tissue Expression, Promoter Analysis, and Its Interaction with Chicken Prolactin (PRL) and Prolactin-like Protein (PRL-L). Molecular and Cellular Endocrinology. 2013, 370(1-2): 149-162 (第一作者, IF 4.241)
◆教学活动
内分泌与代谢(硕士);普通微生物学(本科)
◆指导学生
在读硕士研究生:刘建锋(2021级),雍涛(2021级),郭莎莎(2022级),杨帅(2022级),季煜(2023级),郭莉(2023级)
已毕业硕士研究生:杨铭(2020级,苏黎世大学),余盼(2019级,迈克生物),林英(2018级,五粮液集团),范杰(2017级,科伦药业)