◆个人简历
胡深强,博士,副教授,硕士生导师,动物遗传育种研究中心副主任/党支部副书记。博士毕业于加拿大麦吉尔大学。曾参与国家现代农业产业技术体系、加拿大自然科学与工程研究委员会(NSERC)等项目多项,荣获研究生国家奖学金、Ajinomoto Heartland/Halchemix Award、Graduate Excellence Award、Graduate Research Enhancement and Travel Award等奖学金。2017年就职于动物遗传育种研究所,研究领域主要包括:①水禽生殖系统发育及繁殖活动的激素内分泌调控机制和应用研究;②水禽重要经济性状生理与遗传机理解析、分子标记开发及其育种应用;③水禽新品种/配套系培育及配套养殖技术。目前主持国家自然科学基金青年项目1项、国家重点研发计划项目子课题1项、四川省水禽育种攻关课题1项、四川省科技厅应用基础研究项目1项、四川省自然科学基金面上项目1项、四川省重点实验室自主研究课题1项,主研参与国家自然科学基金面上项目、国家现代农业产业技术体系、四川省畜禽育种攻关等项目多项,指导本科生国家级大学生创新性实验计划项目4项和科研兴趣培养计划项目7项。近年来发表国内外学术论文100余篇,其中以第一或共一或通讯作者在《Frontiers in Cell and Developmental Biology》、《Journal of Steroid Biochemistry and Molecular Biology》、《Frontiers in Endocrinology》、《Domestic Animal Endocrinology》、《BMC Genomics》、《Poultry Science》、《Frontiers in Genetics》、《General and Comparative Endocrinology》、《Theriogenology》、《Animal Reproduction Science》、《Molecular and Cellular Biochemistry》等杂志发表SCI论文30余篇。获国家发明专利授权3项、实用新型专利授权27项,申报国家发明专利3项。2019年主研获神农中华农业科技奖一等奖1项(10/20)。已指导毕业硕士生3名、本科生10余名,协助指导多名博士和硕士生毕业,正在指导在读硕士生7名、本科生6名。
◆科研项目
1. 国家自然科学基金青年项目,31802064,鹅催乳素糖基化对等级前卵泡发育的影响及其调控机制,2019/01-2021/12,在研,主持;
2. 四川省科技厅应用基础研究项目,2019YJ0417,基于RNA-Seq和ATAC-Seq揭示鹅原始卵泡形成与启动募集的分子调控机制,2019/01-2021/01,在研,主持;
3. 畜禽遗传资源发掘与创新利用四川省重点实验室自主研究项目,SNDK-ZZ-201703,DGAT1/2参与调控鹅卵泡颗粒细胞分化的分子机制研究,2018/09-2020/09,在研,主持;
4. 国家自然科学基金面上项目,31972567,基于颗粒层-膜层细胞共培养体系解析miR-202-5p和miR-205a协同调控鹅卵泡选择优势化的分子机制,2020/01-2023/12,在研,主研;
5. 国家自然科学基金面上项目,31672424,鹅颗粒细胞脂肪酸合成对卵泡发育的影响及作用研究,2017/01-2020/12,在研,主研;
6. 国家现代水禽产业技术体系,CARS-42-4,育种技术与方法岗位,2016/01-2020/12,在研,主研;
7. 四川省“十三五”畜禽育种攻关项目,2016NYZ0044,优质特色水禽育种材料与方法创新,2016/01-2020/12,在研,主研;
8. 四川农业大学学科建设双支计划,在研,主持;
9. 指导本科生国家级大学生创新性实验计划项目4项和科研兴趣培养计划项目7项。
◆发表论文
(1) Hu S#; Yang S#; Lu Y; Deng Y; Li L; Zhu J; Zhang Y; Hu B; Hu J; Xia L;He H; Han C; Liu H; Kang B; Li L; Wang J*. Dynamics of the transcriptome and accessible chromatin landscapes during early goose ovarian development. Frontiers in cell and developmental biology 2020, 8, 196.
(2) Hu S#; Liang X#; Ren X#; Shi Y; Su H; Li Y; Du K; Wang J; Jia X; Chen S; Lai S*. Integrated analysis of mRNA and miRNA expression profiles in the ovary of Oryctolagus cuniculus in response to gonadotrophic stimulation. Frontiers in endocrinology 2019, 10, 744.
(3)Li Q#; Hu S#; Wang Y; Deng Y; Yang S; Hu J; Li L; Wang J*. mRNA and miRNA transcriptome profiling of granulosa and theca layers from geese ovarian follicles reveals the crucial pathways and interaction networks for regulation of follicle selection. Frontiers in genetics 2019, 10, 988.
(4) Li Y#; Hu S#; Wang J; Chen S; Jia X; Lai S*. Molecular cloning, polymorphism, and expression analysis of the LKB1/STK11 gene and its association with non-specific digestive disorder in rabbits. Molecular and cellular biochemistry 2018, 449, 127-136.
(5) Hu, S; Zadworny D*. Effects of nonglycosylated and glycosylated prolactin on basal and gonadotropin-stimulated steroidogenesis in chicken ovarian follicles. Domestic animal endocrinology 2017, 61, 27-38.
(6) Hu S; Duggavathi R; Zadworny D*. Expression and regulation of prolactin-like protein messenger RNA in undifferentiated chicken granulosa cells. General and comparative endocrinology 2017, 240, 191-197.
(7) Hu S; Duggavathi R; Zadworny D*. Regulatory mechanisms underlying the expression of prolactin receptor in chicken granulosa cells. PloS one 2017, 12.
(8) Wen R#; Hu S#; Xiao Q; Han C; Gan C; Gou H; Liu H; Li L; Xu H; He H; Wang J*. Leptin exerts proliferative and anti-apoptotic effects on goose granulosa cells through the PI3K/Akt/mTOR signaling pathway. The Journal of steroid biochemistry and molecular biology 2015, 149, 70-79.
(9) Hu S; Liu H; Pan Z; Xia L; Dong X; Li L; Xu F; He H; Wang J*. Molecular cloning, expression profile and transcriptional modulation of two splice variants of very low density lipoprotein receptor during ovarian follicle development in geese (Anser cygnoide). Animal reproduction science 2014, 149, 281-296.
(10) Hu S; Gan C; Wen R; Xiao Q; Gou H; Liu H; Zhang Y; Li L; Wang J*. Role of leptin in the regulation of sterol/steroid biosynthesis in goose granulosa cells. Theriogenology 2014, 82, 677-685.
(11) Hu S#; Cao W#; Yang M; Liu H; Li L; Wang J*. Molecular characterization, tissue distribution, and expression of two ovarian Dicer isoforms during follicle development in goose (Anser cygnoides). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2014, 170, 33-41.
(12) Hu S; Liu H; Pan Z; Ding F; Kou J; Li L; Wang J*. The cloning, characterization, and expression profiling of the LRP8 gene in duck (Anas platyrhynchos). Molecular and cellular biochemistry 2013, 375, 139-149.
(13) 胡深强; 潘志雄; 王继文*. 脂肪甘油三酯脂肪酶 (ATGL) 的生物学功能及调控机制. 中国生物化学与分子生物学报2011, 27(8), 721-727.