◆个人简历
工作单位:
黄娟,四川农业大学, 动物医学院, 讲师
教育经历:
(1)2013-09 至 2018-12, 四川农业大学, 预防兽医学, 博士
(2)2015-09 至 2017-09, 康斯坦茨大学, 免疫学, 联合培养博士
科研与学术工作经历:
(1)2018-12 至 今, 四川农业大学, 动物医学院, 讲师
(2)2012-07 至 2013-08, 四川农业大学, 动物医学院, 助理实验师
近五年主持或参加的省部级以上自然科学基金项目情况:
(1)国家自然科学基金青年基金项目,IL-7和IL-15对鸭坦布苏病毒DNA疫苗长效免疫的作用及机制研究,2020年1月-2022年12月,项目编号31902286,主持。
(2)四川省自然科学基金面上项目,生物佐剂CD40L在鸭坦布苏病毒DNA疫苗长效免疫中的作用及机制研究,20万,2022年1月-2023年12月,项目编号2022NSFSC0079,主持。
(3)国际港澳台科技创新合作,蚊媒黄病毒的3端非编码区特征性重复二级结构调控病毒适应性的分子机制,50万,2022年1月-2024年12月,主研。
个人研究基础简介:
黄娟自博士阶段以来,一直从事禽病毒疫苗佐剂的筛选及新型疫苗的开发。
(1)Huang J, Yu T, Long Z, Wang M, Liu M, Zhu D, Chen S, Zhao X, Yang Q, Wu Y, Zhang S, Ou X, Mao S, Tian B, Gao Q, Sun D, Jia R, Cheng A. Duck IL-7 as a novel adjuvant improves the humoral immune response to an inactivated duck Tembusu virus vaccine[J]. Vet Microbiol. 2023, 279:109665.
(2)Huang J, Yang C, Jia R, Wang M, Chen S, Liu M, Zhu D, Zhao X, Yang Q, Wu Y, Zhang L, Yin Z, Jing B, Cheng A. Induction of a protective response in ducks vaccinated with a DNA vaccine encoding engineered duck circovirus Capsid protein [J]. Vet Microbiol. 2018, 225:40-47.
(3)Huang J, Jia R, Shen H, Wang M, Zhu D, Chen S, Liu M, Zhao X, Wu Y, Yang Q, Yin Z, Cheng A. Oral Delivery of a DNA Vaccine Expressing the PrM and E Genes: A Promising Vaccine Strategy against Flavivirus in Ducks [J]. Sci Rep. 2018, 8(1):12360.
(4)Huang J, Jia R, Brunner T. Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses [J]. Cell Immunol. 2018, 334:1-10.
(5)Seitz C, Huang J, Geiselh?ringer AL, Galbani-Bianchi P, Michalek S, Phan TS, Reinhold C, Dietrich L, Schmidt C, Corazza N, Delgado E, Schnalzger T, Schoonjans K, Brunner T. The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions [J]. Sci Adv. 2019, 5(7):eaav9732.
论著之外的代表性研究成果和学术奖励:
(1)申请国家发明专利1件:黄娟、龙智瑶、贾仁勇、汪铭书、程安春. IL-7作为佐剂在鸭坦布苏病毒灭活疫苗中的应用. 申请号: 202211189311.8.
(2)2019年获农业农村部一等奖1项:“水禽传染病防控关键技术研究和应用创新团队”,排名第11。
(3)2022年获教育部科技进步一等奖1项:“鸭瘟病毒致病机理及免疫防控新技术创制和应用”,排名第5。
◆发表论文
1.Huang J, Yu T, Long Z, Wang M, Liu M, Zhu D, Chen S, Zhao X, Yang Q, Wu Y, Zhang S, Ou X, Mao S, Tian B, Gao Q, Sun D, Jia R, Cheng A. Duck IL-7 as a novel adjuvant improves the humoral immune response to an inactivated duck Tembusu virus vaccine[J]. Vet Microbiol. 2023, 279:109665.
2.Juan Huang, Zhiyao Long, Renyong Jia, et al. The broad immunomodulatory effects of IL-7 and its application in vaccines [J]. Frontiers In Immunology. 2021 Dec,12:680442. doi: doi.org/10.3389/fimmu.2021.680442.
3.Huang J, Zhang Y, Cheng A, Wang M, Liu M, Zhu D, Chen S, Zhao X, Yang Q, Wu Y, Zhang S, Ou X, Mao S, Gao Q, Sun D, Tian B, Yin Z, Jia R. Duck Circovirus genotype 2 ORF3 protein induces apoptosis through the mitochondrial pathway. Poult Sci. 2023 Jan 25;102(4):102533. doi: 10.1016/j.psj.2023.102533.
4.Juan Huang, Renyong Jia, Haoyue Shen, et al. Oral Delivery of a DNA Vaccine Expressing the PrM and E Genes: A Promising Vaccine Strategy against Flavivirus in Ducks [J]. Scientific Reports, 2018, 8(1):12360.
5.Juan Huang, Haoyue Shen, Renyong Jia, et al. Oral Vaccination with a DNA Vaccine Encoding Capsid Protein of Duck Tembusu Virus Induces Protection Immunity [J]. Viruses, 2018, 10(4):180.
6.Juan Huang, Renyong Jia, Thomas Brunner. Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses [J]. Cellular Immunology, 2018,334:1-10.
7.Huang S, Huang J, Cui M, Wu X, Wang M, Zhu D, Chen S, Liu M, Zhao X, Wu Y, Yang Q, Zhang S, Ou X, Mao S, Gao Q, Yu Y, Tian B, Liu Y, Zhang L, Yin Z, Jing B, Chen X, Cheng A, Jia R. Duck Tembusu Virus Inhibits Type I Interferon Production through the JOSD1-SOCS1-IRF7 Negative-Feedback Regulation Pathway [J]. J Virol. 2022 Sep; 96(18): e0093022. doi: 10.1128/jvi.00930-22.
8.Carina Seitz, Juan Huang, Anna-Lena et al. The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions [J]. Science Advances, 2019,5:eaav9732. (IF = 12.804, 1区, Top)
9.Juan Huang, Cui Yang, Renyong Jia et al. Induction of a Protective Response in Ducks Vaccinated with a DNA Vaccine Encoding Engineered Duck Circovirus Capsid Protein [J]. Veterinary Microbiology, 2018, 225:40-47.
10.Juan Huang, Renyong Jia, Mingshu Wang et al. An attenuated duck plague virus (DPV) vaccine induces both systemic and mucosal immune responses to protect ducks against virulent DPV infection [J]. Clinical and Vaccine Immunology, 2014, 21(4):457.