欧旭敏 更新日期：2023-05-15
欧旭敏,男,1988年出生,学硕导师
工作单位 动物医学院
电子邮箱 oxumin@yahoo.com
招生专业 【学硕】:090602预防兽医学，【专硕】:095200兽医
◆个人简历
欧旭敏，男，汉族，1988年11月出生，籍贯为四川青神。本人主要从事遗传密码与tRNA解码相关生物学在人畜禽病毒性肝炎、病毒免疫学及肝癌方向的应用基础研究，致力于解析宿主关键性tRNA的生物学功能。目前主持tRNA相关的四川省科技厅项目1项（2020年，10万）和国家自然科学基金项目1项（2021年，30万）。担任硕士研究生导师、教育部学位中心研究生论文评审专家、Frontiers in Immunology 等杂志审稿人。5年来，共发表SCI论文70篇，授权国家发明专利1项，总访问量5600余次，总他引750余次，年引用率130+，其中第一作者或通讯作者在国际知名期刊发表遗传学、微生物学、免疫学、肝病学相关论文9篇，中科院分区T0P期刊论文5篇，如PNAS、Plos Genetics、Liver International、Journal of Infectious Disease、Transboundary and Emerging Diseases、Frontiers in Immunology等，部分新冠病毒遗传学相关研究入选美国CDC热点话题并被华盛顿州卫生部新冠疫情形势报告收录。tRNA相关病毒学研究和肝癌靶向治疗研究被维基百科收录。
◆工作经历
2019.07-至今：四川农业大学动物医学院预防兽医研究所，讲师
◆教育经历
2017.09-2021.11：荷兰伊拉斯姆斯医学中心，医学博士
2014.09-2019.06：四川农业大学，博士研究生，农学博士
2012.09-2014.06：四川农业大学，直博生，硕士阶段
2010.09-2012.06：黑龙江八一农垦大学，本科，农学学士
2008.10-2010.12：黑龙江大学，本科，工学学士
◆研究领域
共用技术、人禽共患病毒性肝炎。
◆科研项目
干扰素α介导tRNA组改变在抗病毒基因翻译失常中的机理研究，2020YJ0396，四川省科技厅项目，2020/01-2022/12，主持
宿主tRNA调控鸭甲肝病毒在鸡胚细胞中翻译的分子机制,32102706,国家自然科学基金，2022/01-2023/12,主持
◆发表论文
1. Ou, X., Cao, J., Cheng, A., Peppelenbosch, M.P. and Pan, Q., Errors in translational decoding: tRNA wobbling or misincorporation?. PLoS genetics, 2019. 15(3), p.e1008017.
2. Ou, X., Ma, B., Zhang, R., Miao, Z., Cheng, A., Peppelenbosch, M.P. and Pan, Q., A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus. FEBS letters, 2020. 594(12), pp.2005-2015.
3. Ou, X., Peng, W., Yang, Z., Cao, J., Wang, M., Peppelenbosch, M.P., Pan, Q. and Cheng, A., Evolutionarily missing and conserved tRNA genes in human and avian. Infection, Genetics and Evolution, 2020. 85, p.104460.
4. Zhang, R., Noordam, L., Ou, X., Ma, B., Li, Y., Das, P., Shi, S., Liu, J., Wang, L., Li, P. and Verstegen, M.M., The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer. Liver International, 2021. 41(1), pp.206-219.
5. Ou, X., Wang, M., Mao, S., Cao, J., Cheng, A., Zhu, D., Chen, S., Jia, R., Liu, M., Yang, Q. and Wu, Y., Zhao, X. Zhang, S., Liu, Y., Yu, Y., Zhang, L., Chen, X., Peppelenbosch, M.P., Pan, Q. and Cheng, A., Incompatible translation drives a convergent evolution and viral attenuation during the development of live attenuated vaccine. Frontiers in cellular and infection microbiology, 2018. 8, p.249.
6. Ou, X., Mao, S., Cao, J., Cheng, A., Wang, M., Zhu, D., Chen, S., Jia, R., Liu, M., Sun, K. and Yang, Q., Wu, Y., Chen, X., Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1. PloS one, 2017. 12(6), p.e0178993.
7. Ou, X., Mao, S., Cao, J., Ma, Y., Ma, G., Cheng, A., Wang, M., Zhu, D., Chen, S., Jia, R. and Liu, M., The neglected avian hepatotropic virus induces acute and chronic hepatitis in ducks: an alternative model for hepatology. Oncotarget, 2017. 8(47), p.81838.
8. Ou, X., Mao, S., Jiang, Y., Zhang, S., Ke, C., Ma, G., Cheng, A., Wang, M., Zhu, D., Chen, S., Jia, R., Liu, M., Sun, K., Yang, Q, wu., Y, Chen, X. Viral-host interaction in kidney reveals strategies to escape host immunity and persistently shed virus to the urine. Oncotarget 2016. 8:7336-7349.
9. Ou, X., Yang, Z., Zhu, D., Mao, S., Wang, M., Jia, R., Chen, S., Liu, M., Yang, Q., Wu, Y., Zhao, X. Zhang, S., huang, J., Gao, Q., Liu, Y., Zhang, L., Peppelenbosch, M.P., Pan, Q. and Cheng, A., Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2. Transbound Emerg Dis 2021,00:1-13. doi: 10.1111/tbed.14148
10. Miao, Z., Zhang, S., Ou, X., Li, S., Ma, Z., Wang, W., Peppelenbosch, M.P., Liu, J. and Pan, Q., 2020. Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection. The Journal of infectious diseases, 221(10), pp.1677-1687.
11. Li, Y., Qu, C., Yu, P., Ou, X., Pan, Q. and Wang, W., The interplay between host innate immunity and hepatitis E virus. Viruses, 2019. 11(6), p.541.
12. Mao, S., Ou, X., Wang, M., Sun, D., Yang, Q., Wu Y., Jia R., Zhu D., Zhao X., Chen, S., Liu, M., Zhang, S., Huang, J., Gao, Q., Liu Y., Yu, Y., Zhang, L., Tian B., Pan, L., Chen, X., Cheng, A. Duck hepatitis A virus 1 has lymphoid tissue tropism altering the organic immune responses of mature ducks. Transbound Emerg Dis. 2020.doi:10.1111/tbed.13966.
13. Cao, J., Ou, X., Zhu, D., Ma, G., Cheng, A., Wang, M., Chen, S., Jia, R., Liu, M., Sun, K. and Yang, Q., Wu, Y., Chen, X. The 2A2 protein of Duck hepatitis A virus type 1 induces apoptosis in primary cell culture. Virus genes, 2016. 52(6), pp.780-788.
14. Mao, S., Wang, M., Ou, X., Sun, D., Cheng, A., Zhu, D., Chen, S., Jia, R., Liu, M., Sun, K. and Yang, Q., Wu, Y., Zhao, X., Chen, X., Virologic and immunologic characteristics in mature ducks with acute duck hepatitis A virus 1 infection. Frontiers in immunology, 2017.8, p.1574.
15. Xie, J., Zeng, Q., Wang, M., Ou, X., Ma, Y., Cheng, A., Zhao, X.X., Liu, M., Zhu, D., Chen, S. Jia, R., Yang, Q., Wu, Y., Zhang, S., Liu, Y., Yu, Y., Zhang, L. and Chen, X. Transcriptomic characterization of a chicken embryo model infected with duck hepatitis A virus Type 1. Frontiers in immunology, 2018.9, p.1845.
16. Zhu, D., Chen, H., Ou, X., Liu, M., Wang, M., Zhao, X., Jia, R., Chen, S., Sun, K., Yang, Q. and Wu, Y., Chen, X. and Cheng, C., Comparison of immunohistochemistry and Ziehl‐Neelsen staining for detecting the distribution of Mycobacterium avium subsp avium in naturally infected domestic Pekin ducks (Anas platyrhynchos domestica). Veterinary medicine and science, 2020. 6(2), pp.242-247.
17. Zhu, D.K., Song, X.H., Wang, J.B., Zhou, W.S., Ou, X.M., Chen, H.X., Liu, M.F., Wang, M.S., Jia, R.Y., Chen, S. and Sun, K.F., 2016. Outbreak of avian tuberculosis in commercial domestic Pekin ducks (Anas platyrhynchos domestica). Avian Diseases, 60(3), pp.677-680.
◆专著教材
https://repub.eur.nl/pub/136988/
◆指导学生
目前，指导本科生1名，指导硕士研究生6名。